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This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance

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In the STEP-4 clinical trials, participants who discontinued the medication began to regain weight within a few months

High-throughput mRNA sequencing (RNA-Seq) reveals information about the expression of individual genes and makes it possible to identify signaling pathways involved in the development of many diseases